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Apobec1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P41238
Other Accession NP_001635
Clone Names 2072204
Additional Information
Gene ID 339
Other Names C->U-editing enzyme APOBEC-1, 354-, Apolipoprotein B mRNA-editing enzyme 1, HEPR, APOBEC1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1352a was selected from the N-term region of human Apobec1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOBEC1 (HGNC:604)
Function Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs (PubMed:30844405). Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA (PubMed:24916387). Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA (PubMed:11727199). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity).
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed exclusively in the small intestine.
Research Areas
Citations (0)
citation

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Background

APOBEC1 is involved in the production of apolipoprotein B (apoB)-48 from apoB-100. The gene spans 18 kb and contains five exons, all of which are translated. Alternative splicing produces a variant transcript that lacks exon 2 and encodes a novel 36-amino acid peptide. The exon 2-skipped transcript accounts for approximately 50% of APOBEC1 mRNA in the adult small intestine and up to 90% of APOBEC1 mRNA in the developing gut. Exon 2-skipping may thus be a quantitatively important mechanism for regulating the expression of this gene in the gastrointestinal tract.

References

Blanc, V., et al., J. Biol. Chem. 278(42):41198-41204 (2003).Chester, A., et al., EMBO J. 22(15):3971-3982 (2003).Wedekind, J.E., et al., Trends Genet. 19(4):207-216 (2003).Mukhopadhyay, D., et al., Am. J. Hum. Genet. 70(1):38-50 (2002).Dance, G.S., et al., J. Biol. Chem. 277(15):12703-12709 (2002).

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$ 277.78
Cat# BP1352a
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