|Other Names||Stromelysin-1, SL-1, Matrix metalloproteinase-3, MMP-3, Transin-1, MMP3, STMY1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13536a was selected from the N-term region of MMP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. This gene encodes an enzyme whichdegrades fibronectin, laminin, collagens III, IV, IX, and X, andcartilage proteoglycans. The enzyme is thought to be involved inwound repair, progression of atherosclerosis, and tumor initiation.The gene is part of a cluster of MMP genes which localize tochromosome 11q22.3.
Fallah, S., et al. J. Physiol. Biochem. 66(4):359-364(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Skorupski, P., et al. Ginekol. Pol. 81(8):594-599(2010)Yeh, Y.C., et al. BMC Microbiol. 10, 218 (2010) :
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