|Other Names||L-lactate dehydrogenase A chain, LDH-A, Cell proliferation-inducing gene 19 protein, LDH muscle subunit, LDH-M, Renal carcinoma antigen NY-REN-59, LDHA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13542b was selected from the C-term region of LDHA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene catalyzes the conversionof L-lactate and NAD to pyruvate and NADH in the final step ofanaerobic glycolysis. The protein is found predominantly in muscletissue and belongs to the lactate dehydrogenase family. Mutationsin this gene have been linked to exertional myoglobinuria. Multipletranscript variants encoding different isoforms have been found forthis gene. The human genome contains several non-transcribedpseudogenes of this gene.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Zhu, X., et al. Genet. Epidemiol. 34(2):171-187(2010)Zhuang, L., et al. Mod. Pathol. 23(1):45-53(2010)Zhao, Y.H., et al. Oncogene 28(42):3689-3701(2009)Koukourakis, M.I., et al. Oncology 77(5):285-292(2009)
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