|Other Names||Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Vitamin K-dependent protein C light chain, Vitamin K-dependent protein C heavy chain, Activation peptide, PROC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13543c was selected from the Center region of PROC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).|
|Cellular Location||Secreted. Golgi apparatus. Endoplasmic reticulum|
|Tissue Location||Plasma; synthesized in the liver.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a vitamin K-dependent plasmaglycoprotein. The encoded protein is cleaved to its activated formby the thrombin-thrombomodulin complex. This activated formcontains a serine protease domain and functions in degradation ofthe activated forms of coagulation factors V and VIII. Mutations inthis gene have been associated with thrombophilia due to protein Cdeficiency, neonatal purpura fulminans, and recurrent venousthrombosis.
Tang, W., et al. Blood (2010) In press :Agapkina, Iu.V., et al. Mol. Biol. (Mosk.) 44(4):613-619(2010)Witt, I., et al. Blood Coagul. Fibrinolysis 5(4):651-653(1994)Zhang, L., et al. Blood 80(4):942-952(1992)Grundy, C.B., et al. Hum. Genet. 89(6):683-684(1992)
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