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SYT6 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q5T7P8 |
|---|---|
| Clone Names | 110111042 |
| Gene ID | 148281 |
|---|---|
| Other Names | Synaptotagmin-6, Synaptotagmin VI, SytVI, SYT6 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13548b was selected from the C-term region of SYT6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SYT6 |
|---|---|
| Function | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9R0N8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N8} [Isoform 2]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9R0N8}. Cell membrane {ECO:0000250|UniProtKB:Q9R0N8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9R0N8} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Synaptotagmins, such as SYT6, share a common domainstructure that includes a transmembrane domain and a cytoplasmicregion composed of 2 C2 domains. Some synaptotagmins are involvedin synaptic membrane fusion, while others have a more generalfunction in endocytosis. For further information on synaptotagmins,see MIM 185605.
References
Castillo Bennett, J., et al. J. Biol. Chem. 285(34):26269-26278(2010)Dalgin, G.S., et al. J. Urol. 180(3):1126-1130(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Roggero, C.M., et al. Dev. Biol. 285(2):422-435(2005)Craxton, M. Genomics 77 (1-2), 43-49 (2001) :
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