|Other Names||Synaptotagmin-6, Synaptotagmin VI, SytVI, SYT6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13548b was selected from the C-term region of SYT6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)- regulation of exocytosis in acrosomal reaction in sperm (By similarity).|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein Isoform 2: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Synaptotagmins, such as SYT6, share a common domainstructure that includes a transmembrane domain and a cytoplasmicregion composed of 2 C2 domains. Some synaptotagmins are involvedin synaptic membrane fusion, while others have a more generalfunction in endocytosis. For further information on synaptotagmins,see MIM 185605.
Castillo Bennett, J., et al. J. Biol. Chem. 285(34):26269-26278(2010)Dalgin, G.S., et al. J. Urol. 180(3):1126-1130(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Roggero, C.M., et al. Dev. Biol. 285(2):422-435(2005)Craxton, M. Genomics 77 (1-2), 43-49 (2001) :
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