|Other Names||Acetylcholine receptor subunit alpha, CHRNA1, ACHRA, CHNRA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13550b was selected from the C-term region of CHRNA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus|
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Provided below are standard protocols that you may find useful for product applications.
The muscle acetylcholine receptor consiststs of 5 subunitsof 4 different types: 2 alpha isoforms and 1 each of beta, gamma,and delta subunits.2 This gene encodes an alpha subunit that playsa role in acetlycholine binding/channel gating. Alternativelyspliced transcript variants encoding different isoforms have beenidentified.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Ehringer, M.A., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2), 600-609 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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