|Other Names||Eosinophil cationic protein, ECP, 3127-, Ribonuclease 3, RNase 3, RNASE3, ECP, RNS3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13557b was selected from the C-term region of RNASE3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.|
|Cellular Location||Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus|
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Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity.
Peona, V., et al. J Asthma 47(2):131-134(2010)Kang, I., et al. Eur Arch Otorhinolaryngol 267(3):391-395(2010)Jonsson, U.B., et al. BMC Pulm Med 10, 36 (2010) :Kato, M., et al. Int. Arch. Allergy Immunol. 152 SUPPL 1, 62-66 (2010) :Chang, K.C., et al. BMC Cell Biol. 11, 6 (2010) :
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