|Other Names||Vacuole membrane protein 1, Transmembrane protein 49, VMP1, TDC1, TMEM49|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13559b was selected from the C-term region of TMEM49. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.|
|Cellular Location||Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein. Vacuole membrane; Multi-pass membrane protein Endoplasmic reticulum|
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Provided below are standard protocols that you may find useful for product applications.
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity).
Pardo, R., et al. Pancreatology 10(1):19-26(2010)Calvo-Garrido, J., et al. Mol. Biol. Cell 19(8):3442-3453(2008)Fujita, S., et al. J. Mol. Biol. 378(3):492-504(2008)Sauermann, M., et al. Oncogene 27(9):1320-1326(2008)Ropolo, A., et al. J. Biol. Chem. 282(51):37124-37133(2007)
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