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NFE2 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q16621
Clone Names 100318135
Peptide ID 100318135
Additional Information
Gene ID 4778
Other Names Transcription factor NF-E2 45 kDa subunit, Leucine zipper protein NF-E2, Nuclear factor, erythroid-derived 2 45 kDa subunit, p45 NF-E2, NFE2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13561b was selected from the C-term region of NFE2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NFE2
Function Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Cellular Location Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH
Tissue Location Expressed in hematopoietic cells and also in colon and testis
Research Areas
Citations (0)

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Background

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.

References

Wang, W., et al. Blood 116(2):254-266(2010)Zhou, Z., et al. J. Biol. Chem. 285(21):15894-15905(2010)Motohashi, H., et al. Blood 115(3):677-686(2010)Lee, T.L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(1):52-57(2010)Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)

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$ 80.00
Cat# BP13561b
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