|Other Names||Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Protein Mob, Sphingomyelin synthase 1, Transmembrane protein 23, SGMS1, MOB, SMS1, TMEM23|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13562a was selected from the N-term region of SGMS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||MOB, SMS1, TMEM23|
|Function||Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein|
|Tissue Location||Brain, heart, kidney, liver, muscle and stomach.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is predicted to be afive-pass transmembrane protein. This gene may be predominatelyexpressed in brain.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lafont, E., et al. Cell Death Differ. 17(4):642-654(2010)Vacaru, A.M., et al. J. Cell Biol. 185(6):1013-1027(2009)Wang, W., et al. Plant Cell 20(11):3163-3179(2008)Jin, Z.X., et al. Int. Immunol. 20(11):1427-1437(2008)
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