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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   SGMS1 Antibody (N-term) Blocking peptide   

SGMS1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q86VZ5
Clone Names 100324054
Peptide ID 100324054
Additional Information
Gene ID 259230
Other Names Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Protein Mob, Sphingomyelin synthase 1, Transmembrane protein 23, SGMS1, MOB, SMS1, TMEM23
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13562a was selected from the N-term region of SGMS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SGMS1
Synonyms MOB, SMS1, TMEM23
Function Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
Cellular Location Golgi apparatus membrane; Multi-pass membrane protein
Tissue Location Brain, heart, kidney, liver, muscle and stomach.
Research Areas
Citations (0)

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The protein encoded by this gene is predicted to be afive-pass transmembrane protein. This gene may be predominatelyexpressed in brain.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lafont, E., et al. Cell Death Differ. 17(4):642-654(2010)Vacaru, A.M., et al. J. Cell Biol. 185(6):1013-1027(2009)Wang, W., et al. Plant Cell 20(11):3163-3179(2008)Jin, Z.X., et al. Int. Immunol. 20(11):1427-1437(2008)

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$ 80.00
Cat# BP13562a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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