|Other Names||Zinc finger X-chromosomal protein, ZFX|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13564c was selected from the Center region of ZFX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable transcriptional activator.|
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Provided below are standard protocols that you may find useful for product applications.
This gene on the X chromosome is structurally similar to arelated gene on the Y chromosome. It encodes a member of thekrueppel C2H2-type zinc-finger protein family. The full-lengthprotein contains an acidic transcriptional activation domain (AD),a nuclear localization sequence (NLS) and a DNA binding domain(DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouseembryonic and adult hematopoietic stem cells showed that this genewas required as a transcriptional regulator for self-renewal ofboth stem cell types, but it was dispensable for growth anddifferentiation of their progeny. Multiple alternatively splicedtranscript variants encoding different isoforms have beenidentified, but the full-length nature of some variants has notbeen determined.
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Poloumienko, A. Genome 47(1):74-83(2004)Agate, R.J., et al. Mol. Biol. Evol. 21(2):384-396(2004)Murphy, W.J., et al. Nature 409(6820):614-618(2001)Taylor, D.M., et al. Mol. Reprod. Dev. 48(4):442-448(1997)
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