|Other Names||Adenylate cyclase type 4, ATP pyrophosphate-lyase 4, Adenylate cyclase type IV, Adenylyl cyclase 4, ADCY4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13565a was selected from the N-term region of ADCY4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm|
|Tissue Location||Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the family of adenylatecyclases, which are membrane-associated enzymes that catalyze theformation of the secondary messenger cyclic adenosine monophosphate(cAMP). Mouse studies show that adenylate cyclase 4, along withadenylate cyclases 2 and 3, is expressed in olfactory cilia,suggesting that several different adenylate cyclases may couple toolfactory receptors and that there may be multiplereceptor-mediated mechanisms for the generation of cAMP signals.Alternative splicing results in transcript variants. [provided byRefSeq].
Rhim, J.H., et al. Aging Cell 5(6):451-461(2006)Sunahara, R.K., et al. Mol. Interv. 2(3):168-184(2002)Ludwig, M.G., et al. J. Recept. Signal Transduct. Res. 22 (1-4), 79-110 (2002) :Cote, M., et al. J. Clin. Endocrinol. Metab. 86(9):4495-4503(2001)Patrizio, M., et al. J. Neurochem. 77(2):399-407(2001)
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