|Other Names||Adenylate cyclase type 4, ATP pyrophosphate-lyase 4, Adenylate cyclase type IV, Adenylyl cyclase 4, ADCY4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13565a was selected from the N-term region of ADCY4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm|
|Tissue Location||Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the family of adenylatecyclases, which are membrane-associated enzymes that catalyze theformation of the secondary messenger cyclic adenosine monophosphate(cAMP). Mouse studies show that adenylate cyclase 4, along withadenylate cyclases 2 and 3, is expressed in olfactory cilia,suggesting that several different adenylate cyclases may couple toolfactory receptors and that there may be multiplereceptor-mediated mechanisms for the generation of cAMP signals.Alternative splicing results in transcript variants. [provided byRefSeq].
Rhim, J.H., et al. Aging Cell 5(6):451-461(2006)Sunahara, R.K., et al. Mol. Interv. 2(3):168-184(2002)Ludwig, M.G., et al. J. Recept. Signal Transduct. Res. 22 (1-4), 79-110 (2002) :Cote, M., et al. J. Clin. Endocrinol. Metab. 86(9):4495-4503(2001)Patrizio, M., et al. J. Neurochem. 77(2):399-407(2001)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.