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ADCY4 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NFM4
Clone Names 100324205
Peptide ID 100324205
Additional Information
Gene ID 196883
Other Names Adenylate cyclase type 4, ATP pyrophosphate-lyase 4, Adenylate cyclase type IV, Adenylyl cyclase 4, ADCY4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13565a was selected from the N-term region of ADCY4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADCY4
Function Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasm
Tissue Location Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level)
Research Areas
Citations (0)

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Background

This gene encodes a member of the family of adenylatecyclases, which are membrane-associated enzymes that catalyze theformation of the secondary messenger cyclic adenosine monophosphate(cAMP). Mouse studies show that adenylate cyclase 4, along withadenylate cyclases 2 and 3, is expressed in olfactory cilia,suggesting that several different adenylate cyclases may couple toolfactory receptors and that there may be multiplereceptor-mediated mechanisms for the generation of cAMP signals.Alternative splicing results in transcript variants. [provided byRefSeq].

References

Rhim, J.H., et al. Aging Cell 5(6):451-461(2006)Sunahara, R.K., et al. Mol. Interv. 2(3):168-184(2002)Ludwig, M.G., et al. J. Recept. Signal Transduct. Res. 22 (1-4), 79-110 (2002) :Cote, M., et al. J. Clin. Endocrinol. Metab. 86(9):4495-4503(2001)Patrizio, M., et al. J. Neurochem. 77(2):399-407(2001)

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$ 80.00
Cat# BP13565a
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