|Other Names||Interleukin-26, IL-26, Protein AK155, IL26, AK155|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13569a was selected from the N-term region of IL26. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.|
|Tissue Location||Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This gene was identified by its overexpressionspecifically in herpesvirus samimiri-transformed T cells. Theencoded protein is a member of the IL10 family of cytokines. It isa secreted protein and may function as a homodimer. This protein isthought to contribute to the transformed phenotype of T cells afterinfection by herpesvirus samimiri.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Wang, K., et al. Hum. Mol. Genet. 19(10):2059-2067(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
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