IL26 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NPH9 |
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Clone Names | 100405084 |
Gene ID | 55801 |
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Other Names | Interleukin-26, IL-26, Protein AK155, IL26, AK155 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13569a was selected from the N-term region of IL26. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | IL26 |
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Synonyms | AK155 |
Function | May play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. |
Cellular Location | Secreted. |
Tissue Location | Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T- cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene was identified by its overexpressionspecifically in herpesvirus samimiri-transformed T cells. Theencoded protein is a member of the IL10 family of cytokines. It isa secreted protein and may function as a homodimer. This protein isthought to contribute to the transformed phenotype of T cells afterinfection by herpesvirus samimiri.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Wang, K., et al. Hum. Mol. Genet. 19(10):2059-2067(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
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