|Other Names||Interleukin-26, IL-26, Protein AK155, IL26, AK155|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13569a was selected from the N-term region of IL26. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.|
|Tissue Location||Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene was identified by its overexpressionspecifically in herpesvirus samimiri-transformed T cells. Theencoded protein is a member of the IL10 family of cytokines. It isa secreted protein and may function as a homodimer. This protein isthought to contribute to the transformed phenotype of T cells afterinfection by herpesvirus samimiri.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Wang, K., et al. Hum. Mol. Genet. 19(10):2059-2067(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.