|Other Names||Ubiquitin carboxyl-terminal hydrolase 40, Deubiquitinating enzyme 40, Ubiquitin thioesterase 40, Ubiquitin-specific-processing protease 40, USP40|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13572a was selected from the N-term region of USP40. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be catalytically inactive.|
|Tissue Location||Broadly expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Modification of cellular proteins by ubiquitin is anessential regulatory mechanism controlled by the coordinated actionof multiple ubiquitin-conjugating and deubiquitinating enzymes.USP40 belongs to a large family of cysteine proteases that functionas deubiquitinating enzymes (Quesada et al., 2004 [PubMed14715245]).
Wu, Y.R., et al. Clin. Chim. Acta 411 (13-14), 955-958 (2010) :Li, Y., et al. Hum. Mutat. 27(10):1017-1023(2006)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Quesada, V., et al. Biochem. Biophys. Res. Commun. 314(1):54-62(2004)Puente, X.S., et al. Nat. Rev. Genet. 4(7):544-558(2003)
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