|Other Names||Plexin-C1, Virus-encoded semaphorin protein receptor, CD232, PLXNC1, VESPR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13576b was selected from the C-term region of PLXNC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in heart, brain, lung, spleen and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
PLXNC1 is a receptor for vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of viral semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).
Liu, H., et al. Cell 142(5):749-761(2010)Lazova, R., et al. Am J Dermatopathol 31(2):177-181(2009)Scott, G.A., et al. J. Invest. Dermatol. 129(4):954-963(2009)Scott, G.A., et al. J. Invest. Dermatol. 128(1):151-161(2008)Li, Y., et al. PLoS ONE 3 (7), E2707 (2008) :
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