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EMP2 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P54851
Clone Names 100324021
Peptide ID 100324021
Additional Information
Gene ID 2013
Other Names Epithelial membrane protein 2, EMP-2, Protein XMP, EMP2, XMP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13581b was selected from the C-term region of EMP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EMP2
Synonyms XMP
Function Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration and cell contraction through PTK2 and SRC activation (PubMed:21637765, PubMed:22728127). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PubMed:19494199). Positively regulates cell proliferation (PubMed:24814193). Plays a role during cell death and cell blebbing (PubMed:12107182). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PubMed:23334331). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16487956). May play a role in glomerular filtration (By similarity).
Cellular Location Golgi apparatus membrane {ECO:0000250|UniProtKB:O88662}; Multi-pass membrane protein. Cell membrane. Apical cell membrane {ECO:0000250|UniProtKB:O88662}. Membrane raft. Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q66HH2}. Note=Localizes in cytoplasm, foot processes and cell bodies of podocytes and nucleus of endothelial cells of kidney. Localizes to the apical cell surface in the luminal epithelium and glandular epithelium. Colocalized with ITGB1 and GPI-anchor proteins on plasma membrane {ECO:0000250|UniProtKB:O88662, ECO:0000250|UniProtKB:Q66HH2}
Tissue Location Expressed in ciliary body epithelia, sclera, cornea, and retinal pigment epithelium (at protein level) (PubMed:12710941).
Research Areas
Citations (0)

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The function of this protein remains unknown.


Mick, E., et al. J Am Acad Child Adolesc Psychiatry 49(9):898-905(2010)Fu, M., et al. Clin. Cancer Res. 16(15):3954-3963(2010)Shimazaki, K., et al. Clin. Cancer Res. 14(22):7367-7377(2008)Wadehra, M., et al. Reprod. Biol. Endocrinol. 6, 15 (2008) :Forbes, A., et al. J. Biol. Chem. 282(36):26542-26551(2007)

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$ 80.00
Cat# BP13581b
Availability: In Stock
Bulk Size
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