|Other Names||Coronin-2A, IR10, WD repeat-containing protein 2, CORO2A, IR10, WDR2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13589c was selected from the Center region of CORO2A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the WD repeat proteinfamily. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),which may facilitate formation of heterotrimeric or multiproteincomplexes. Members of this family are involved in a variety ofcellular processes, including cell cycle progression, signaltransduction, apoptosis, and gene regulation. This protein contains5 WD repeats, and has a structural similarity with actin-bindingproteins: the D. discoideum coronin and the human p57 protein,suggesting that this protein may also be an actin-binding proteinthat regulates cell motility. Alternative splicing of this genegenerates 2 transcript variants.
Jin, Y., et al. Nat. Genet. 42(7):576-578(2010)Marshall, T.W., et al. J. Cell. Sci. 122 (PT 17), 3061-3069 (2009) :Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Yoon, H.G., et al. Mol. Cell 12(3):723-734(2003)Yoon, H.G., et al. EMBO J. 22(6):1336-1346(2003)
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