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FSHB/FSH Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01225 |
|---|---|
| Clone Names | 101229005 |
| Gene ID | 2488 |
|---|---|
| Other Names | Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain, FSHB |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13591c was selected from the Center region of FSHB/FSH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FSHB |
|---|---|
| Function | Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432). |
| Cellular Location | Secreted. Note=Efficient secretion requires dimerization with CGA |
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Provided below are standard protocols that you may find useful for product applications.
Background
The pituitary glycoprotein hormone family includesfollicle-stimulating hormone, luteinizing hormone, chorionicgonadotropin, and thyroid-stimulating hormone. All of theseglycoproteins consist of an identical alpha subunit and ahormone-specific beta subunit. This gene encodes the beta subunitof follicle-stimulating hormone. In conjunction with luteinizinghormone, follicle-stimulating hormone induces egg and spermproduction. Alternative splicing results in two transcript variantsencoding the same protein.
References
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Corpuz, P.S., et al. Mol. Endocrinol. 24(5):1037-1051(2010)Grigorova, M., et al. J. Clin. Endocrinol. Metab. 95(1):100-108(2010)Ahn, J., et al. Hum. Mol. Genet. 18(19):3749-3757(2009)Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)
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