|Other Names||Protein cornichon homolog 1, CNIH-1, Cornichon family AMPA receptor auxiliary protein 1, Protein cornichon homolog, T-cell growth-associated molecule 77, TGAM77, CNIH1, CNIH, CNIL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13594b was selected from the C-term region of CNIH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the selective transport and maturation of TGF-alpha family proteins.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane. Note=Located primarily in the ER; may cycle between the ER and the Golgi apparatus|
|Tissue Location||Highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes and bone marrow Lower expression found in brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus and fetal liver Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study)|
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Provided below are standard protocols that you may find useful for product applications.
CNIH is involved in the selective transport and maturation of TGF-alpha family proteins.
Castro, C.P., et al. J. Cell. Sci. 120 (PT 14), 2454-2466 (2007) :Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Utku, N., et al. Biochim. Biophys. Acta 1449(3):203-210(1999)
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