|Other Names||Selenoprotein K, SelK, SELK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13595c was selected from the Center region of SELK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum- associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low- density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (PubMed:20692228). Protects cells from oxidative stress when overexpressed in cardiomyocytes (PubMed:16962588).|
|Cellular Location||Endoplasmic reticulum membrane; Single- pass membrane protein. Cell membrane; Single-pass membrane protein. Note=Probably mainly localized in the ER|
|Tissue Location||Highly expressed in heart.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a selenoprotein, which contains aselenocysteine (Sec) residue at its active site. The selenocysteineis encoded by the UGA codon that normally signals translationtermination. The 3' UTR of selenoprotein genes have a commonstem-loop structure, the sec insertion sequence (SECIS), that isnecessary for the recognition of UGA as a Sec codon rather than asa stop signal. This selenoprotein is localized to the endoplasmicreticulum and is highly expressed in the heart, where it mayfunction as an antioxidant.
Lu, C., et al. FEBS Lett. 580(22):5189-5197(2006)Kryukov, G.V., et al. Science 300(5624):1439-1443(2003)
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