|Other Names||LIM and senescent cell antigen-like-containing domain protein 2, LIM-like protein 2, Particularly interesting new Cys-His protein 2, PINCH-2, LIMS2, PINCH2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13597b was selected from the C-term region of LIMS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.|
|Cellular Location||Nucleus. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
LIMS2 is a focal adhesion protein that associates withintegrin-linked kinase (ILK; MIM 602366), a multidomain proteinthat mediates multiple protein-protein interactions at adhesionsites between cells and the extracellular matrix (ECM).[supplied byOMIM].
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Kim, S.K., et al. Biochem. Biophys. Res. Commun. 349(3):1032-1040(2006)Zhang, Y., et al. J. Biol. Chem. 277(41):38328-38338(2002)Tu, Y., et al. J. Cell Biol. 153(3):585-598(2001)
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