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STX17 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P56962
Clone Names 100406193
Peptide ID 100406193
Additional Information
Gene ID 55014
Other Names Syntaxin-17, STX17
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13599a was selected from the N-term region of STX17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STX17 (HGNC:11432)
Function SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z158} Note=Has a hairpin-like insertion into membranes. Localizes to the completed autophagosome membrane upon cell starvation (PubMed:23217709). May also localize to the mitochondria according to PubMed:23217709.
Research Areas
Citations (0)

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Implicated in vesicle trafficking to lysosomes. STX17 could be involved in processes related to cell division (By similarity).


Petukhova, L., et al. Nature 466(7302):113-117(2010)Zhao, Z.Z., et al. Melanoma Res. 19(2):80-86(2009)Steegmaier, M., et al. Mol. Biol. Cell 11(8):2719-2731(2000)Steegmaier, M., et al. J. Biol. Chem. 273(51):34171-34179(1998)

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$ 80.00
Cat# BP13599a
Availability: In Stock
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