|Other Names||Syntaxin-17, STX17|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13599a was selected from the N-term region of STX17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytosol. Note=Has an hairpin-like insertion into membranes. Localized into endoplasmic reticulum membranes, it also localizes to the completed autophagosome membrane upon cell starvation. May also localize to the mitochondria according to PubMed:23217709. A significant amount is also present in the cytosol|
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Provided below are standard protocols that you may find useful for product applications.
Implicated in vesicle trafficking to lysosomes. STX17 could be involved in processes related to cell division (By similarity).
Petukhova, L., et al. Nature 466(7302):113-117(2010)Zhao, Z.Z., et al. Melanoma Res. 19(2):80-86(2009)Steegmaier, M., et al. Mol. Biol. Cell 11(8):2719-2731(2000)Steegmaier, M., et al. J. Biol. Chem. 273(51):34171-34179(1998)
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