|Other Names||Podocalyxin-like protein 2, Endoglycan, PODXL2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13602b was selected from the C-term region of PODXL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in T-cells, B-cells and monocytes. Expression is higher on memory and germinal center cells than on naive B-cells (at protein level). Highly expressed in brain Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells.|
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Provided below are standard protocols that you may find useful for product applications.
Endoglycan is a disulfide-linked homodimeric membrane protein belongong to the podocalyxin family.
Kerr, S.C., et al. J. Immunol. 181(2):1480-1490(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Fieger, C.B., et al. J. Biol. Chem. 278(30):27390-27398(2003)
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