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PCDHB7 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y5E2
Clone Names 101008023
Peptide ID 101008023
Additional Information
Other Names Protocadherin beta-7, PCDH-beta-7, PCDHB7
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13605b was selected from the C-term region of PCDHB7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCDHB7
Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Cellular Location Cell membrane; Single-pass type I membrane protein EMBL; AF152500; AAD43761.1; -; mRNA EMBL; AF217750; AAK51617.1; -; mRNA EMBL; AK315054; BAG37530.1; -; mRNA EMBL; CH471062; EAW61977.1; -; Genomic_DNA EMBL; BC130331; AAI30332.1; -; mRNA CCDS; CCDS4249.1; - RefSeq; NP_061763.1; NM_018940.3 UniGene; Hs.203830; - ProteinModelPortal; Q9Y5E2; - SMR; Q9Y5E2; - BioGrid; 121069; 17 STRING; 9606.ENSP00000231137; - iPTMnet; Q9Y5E2; - PhosphoSitePlus; Q9Y5E2; - BioMuta; PCDHB7; - DMDM; 13431373; - EPD; Q9Y5E2; - PaxDb; Q9Y5E2; - PeptideAtlas; Q9Y5E2; - PRIDE; Q9Y5E2; - ProteomicsDB; 86341; - DNASU; 56129; - Ensembl; ENST00000231137; ENSP00000231137; ENSG00000113212 GeneID; 56129; - KEGG; hsa:56129; - UCSC; uc003lit.5; human CTD; 56129; - EuPathDB; HostDB:ENSG00000113212.6; - GeneCards; PCDHB7; - HGNC; HGNC:8692; PCDHB7 HPA; HPA059271; - MIM; 604967; gene MIM; 606333; gene neXtProt; NX_Q9Y5E2; - OpenTargets; ENSG00000113212; - PharmGKB; PA33041; - eggNOG; KOG3594; Eukaryota eggNOG; ENOG410XQHI; LUCA GeneTree; ENSGT00920000148964; - HOGENOM; HOG000220892; - HOVERGEN; HBG054878; - InParanoid; Q9Y5E2; - KO; K16494; - OMA; NAKMVCS; - OrthoDB; EOG091G024L; - PhylomeDB; Q9Y5E2; - TreeFam; TF332299; - GeneWiki; PCDHB7; - GenomeRNAi; 56129; - PRO; PR:Q9Y5E2; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000113212; - CleanEx; HS_PCDHB7; - Genevisible; Q9Y5E2; HS GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central GO; GO:0005509; F:calcium ion binding; IEA:InterPro GO; GO:0007155; P:cell adhesion; IBA:GO_Central GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro GO; GO:0007416; P:synapse assembly; IBA:GO_Central InterPro; IPR002126; Cadherin InterPro; IPR015919; Cadherin-like InterPro; IPR032455; Cadherin_C InterPro; IPR020894; Cadherin_CS InterPro; IPR013164; Cadherin_N InterPro; IPR030741; PCDHB7 PANTHER; PTHR24028:SF69; PTHR24028:SF69; 1 Pfam; PF00028; Cadherin; 5 Pfam; PF08266; Cadherin_2; 1 Pfam; PF16492; Cadherin_C_2; 1 PRINTS; PR00205; CADHERIN SMART; SM00112; CA; 5 SUPFAM; SSF49313; SSF49313; 6 PROSITE; PS00232; CADHERIN_1; 5 PROSITE; PS50268; CADHERIN_2; 5 2: Evidence at transcript level; Calcium; Cell adhesion; Cell membrane; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 26 CHAIN 27 793 Protocadherin beta-7 /FTId=PRO_0000003926 TOPO_DOM 27 688 Extracellular. TRANSMEM 689 709 Helical. TOPO_DOM 710 793 Cytoplasmic. DOMAIN 35 133 Cadherin 1. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 138 242 Cadherin 2. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 247 347 Cadherin 3. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 352 451 Cadherin 4. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 456 561 Cadherin 5. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 568 671 Cadherin 6. {ECO:0000255|PROSITE- ProRule:PRU00043} CARBOHYD 169 169 N-linked (GlcNAc...) asparagine CARBOHYD 418 418 N-linked (GlcNAc...) asparagine CARBOHYD 436 436 N-linked (GlcNAc...) asparagine CARBOHYD 567 567 N-linked (GlcNAc...) asparagine VARIANT 120 120 E -> K (in dbSNP:rs17286891) /FTId=VAR_033708 VARIANT 187 187 E -> K (in dbSNP:rs17096946) /FTId=VAR_033709 VARIANT 389 389 V -> L (in dbSNP:rs2910313) /FTId=VAR_020367 VARIANT 575 575 P -> L (in dbSNP:rs13189280) /FTId=VAR_059183 VARIANT 576 576 L -> V (in dbSNP:rs13174866) /FTId=VAR_059184 VARIANT 716 716 R -> W (in dbSNP:rs2910314) /FTId=VAR_059185 SEQUENCE 793 AA; 86707 MW; E5677098653CC755 CRC64; MEARVERAVQ KRQVLFLCVF LGMSWAGAEP LRYFVAEETE RGTFLTNLAK DLGLGVGELR ARGTRIVSDQ NMQILLLSSL TGDLLLNEKL DREELCGPRE PCVLPFQLLL EKPFQIFRAE LWVRDINDHA PVFLDREISL KILESTTPGA AFLLESAQDS DVGTNSLSNY TISPNAYFHI NVHDSGEGNI YPELVLNQVL DREEIPEFSL TLTALDGGSP PRSGTALVRI LVLDVNDNAP DFVRSLYKVQ VPENSPVGSM VVSVSARDLD TGSNGEIAYA FSYATERILK TFQINPTSGS LHLKAQLDYE AIQTYTLTIQ AKDGGGLSGK CTVVVDVTDI NDNRPELLLS SLTSPIAENS PETVVAVFRI RDRDSGNNGK TVCSIQDDVP FILKPSVENF YTLVTEKPLD RERNTEYNIT ITVTDLGTPR LKTEHNITVL VSDVNDNAPA FTQTSYTLFV RENNSPALPI GSVSATDRDS GTNAQVIYSL LPSQDPHLPL ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSSEALVRVL VLDANDNSPF VLYPLQNSSA PCTEPLPRAA EPGYLVTKVV AVDGDSGQNA WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP PRSATATLHV LLVDGFSQPY LRLPEAAPDQ ANSLTVYLVV ALASVSSLFL LSVLLFVAVR LCRRSRAAPV GRCSVPEGPF PRHLVDLSGT GTLSQSYQYE VCLTGGSGTN EFKFLKPIIP NLLPQSTGRE VEENRPFQNN LGF
Research Areas
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Background

This gene is a member of the protocadherin beta genecluster, one of three related gene clusters tandemly linked onchromosome five. The gene clusters demonstrate an unusual genomicorganization similar to that of B-cell and T-cell receptor geneclusters. The beta cluster contains 16 genes and 3 pseudogenes,each encoding 6 extracellular cadherin domains and a cytoplasmictail that deviates from others in the cadherin superfamily. Theextracellular domains interact in a homophilic manner to specifydifferential cell-cell connections. Unlike the alpha and gammaclusters, the transcripts from these genes are made up of only onelarge exon, not sharing common 3' exons as expected. These neuralcadherin-like cell adhesion proteins are integral plasma membraneproteins. Their specific functions are unknown but they most likelyplay a critical role in the establishment and function of specificcell-cell neural connections. The transcript for this particularfamily member uses more than one polyadenylation site. [provided byRefSeq].

References

Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Vanhalst, K., et al. FEBS Lett. 495 (1-2), 120-125 (2001) :Wu, Q., et al. Genome Res. 11(3):389-404(2001)Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)

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$ 80.00
Cat# BP13605b
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