SLC6A20 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NP91 |
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Clone Names | 110111048 |
Gene ID | 54716 |
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Other Names | Sodium- and chloride-dependent transporter XTRP3, Sodium/imino-acid transporter 1, Solute carrier family 6 member 20, Transporter rB21A homolog, SLC6A20, SIT1, XT3, XTRP3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13608b was selected from the C-term region of SLC6A20. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC6A20 (HGNC:30927) |
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Function | Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids (PubMed:15632147, PubMed:19033659, PubMed:33428810). Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (PubMed:33428810). |
Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:Q8VDB9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8VDB9}. Note=Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi {ECO:0000250|UniProtKB:Q8VDB9} |
Tissue Location | Kidney and small intestine. Expressed in the S3 segment of the proximal tubule. Expressed in neurons (PubMed:33428810) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transport of small hydrophilic substances across cellmembranes is mediated by substrate-specific transporter proteinswhich have been classified into several families of related genes.The protein encoded by this gene is a member of the subgroup oftransporter with unidentified substrates within the Na+ and Cl-coupled transporter family. This gene is expressed in kidney, andits alternative splicing generates 2 transcript variants. [providedby RefSeq].
References
Broer, A., et al. Mol. Membr. Biol. 26(5):333-346(2009)Broer, S. Physiol. Rev. 88(1):249-286(2008)Takanaga, H., et al. J. Biol. Chem. 280(10):8974-8984(2005)Kanei-Ishii, C., et al. J. Biol. Chem. 279(43):44582-44589(2004)Kiss, H., et al. Genomics 73(1):10-19(2001)
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