|Other Names||Sodium- and chloride-dependent transporter XTRP3, Sodium/imino-acid transporter 1, Solute carrier family 6 member 20, Transporter rB21A homolog, SLC6A20, SIT1, XT3, XTRP3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13608b was selected from the C-term region of SLC6A20. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||SIT1, XT3, XTRP3|
|Function||Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine.|
|Cellular Location||Apical cell membrane; Multi- pass membrane protein. Note=Located in the apical brush border membrane of kidney proximal tubule cells|
|Tissue Location||Kidney and small intestine. Expressed in the S3 segment of the proximal tubule.|
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Provided below are standard protocols that you may find useful for product applications.
Transport of small hydrophilic substances across cellmembranes is mediated by substrate-specific transporter proteinswhich have been classified into several families of related genes.The protein encoded by this gene is a member of the subgroup oftransporter with unidentified substrates within the Na+ and Cl-coupled transporter family. This gene is expressed in kidney, andits alternative splicing generates 2 transcript variants. [providedby RefSeq].
Broer, A., et al. Mol. Membr. Biol. 26(5):333-346(2009)Broer, S. Physiol. Rev. 88(1):249-286(2008)Takanaga, H., et al. J. Biol. Chem. 280(10):8974-8984(2005)Kanei-Ishii, C., et al. J. Biol. Chem. 279(43):44582-44589(2004)Kiss, H., et al. Genomics 73(1):10-19(2001)
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