|Other Names||T-lymphoma invasion and metastasis-inducing protein 2, TIAM-2, SIF and TIAM1-like exchange factor, TIAM2, KIAA2016, STEF|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13610a was selected from the N-term region of TIAM2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.|
|Cellular Location||Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites.|
|Tissue Location||Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a guanine nucleotide exchange factor. Ahighly similar mouse protein specifically activates ras-related C3botulinum substrate 1, converting this Rho-like guanosinetriphosphatase (GTPase) from a guanosine diphosphate-bound inactivestate to a guanosine triphosphate-bound active state. The encodedprotein may play a role in neural cell development. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Rabizadeh, S., et al. Cytokine Growth Factor Rev. 14 (3-4), 225-239 (2003) :Salehi, A.H., et al. J. Biol. Chem. 277(50):48043-48050(2002)Yoshizawa, M., et al. Mech. Dev. 113(1):65-68(2002)Harrington, A.W., et al. J. Neurosci. 22(1):156-166(2002)
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