|Other Names||Protein naked cuticle homolog 1, Naked-1, hNkd, hNkd1, NKD1, NKD|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13613a was selected from the N-term region of NKD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.|
|Cellular Location||Cell membrane. Cytoplasm|
|Tissue Location||Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
In the mouse, Nkd is a Dishevelled (see DVL1; MIM601365)-binding protein that functions as a negative regulator ofthe Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf(see MIM 602272) signaling pathway.
Guo, J., et al. PLoS ONE 4 (11), E7982 (2009) :Creyghton, M.P., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5397-5402(2006)Creyghton, M.P., et al. Genes Dev. 19(3):376-386(2005)Yan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 98(26):14973-14978(2001)Katoh, M. Int. J. Oncol. 19(5):963-969(2001)
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