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NKD1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q969G9 |
|---|---|
| Clone Names | 100406266 |
| Gene ID | 85407 |
|---|---|
| Other Names | Protein naked cuticle homolog 1, Naked-1, hNkd, hNkd1, NKD1, NKD |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13613a was selected from the N-term region of NKD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NKD1 |
|---|---|
| Synonyms | NKD |
| Function | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. |
| Cellular Location | Cell membrane. Cytoplasm |
| Tissue Location | Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen. |
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Provided below are standard protocols that you may find useful for product applications.
Background
In the mouse, Nkd is a Dishevelled (see DVL1; MIM601365)-binding protein that functions as a negative regulator ofthe Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf(see MIM 602272) signaling pathway.
References
Guo, J., et al. PLoS ONE 4 (11), E7982 (2009) :Creyghton, M.P., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5397-5402(2006)Creyghton, M.P., et al. Genes Dev. 19(3):376-386(2005)Yan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 98(26):14973-14978(2001)Katoh, M. Int. J. Oncol. 19(5):963-969(2001)
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