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FOLR3 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P41439
Clone Names 100406281
Additional Information
Gene ID 2352
Other Names Folate receptor gamma, FR-gamma, Folate receptor 3, FOLR3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13617a was selected from the N-term region of FOLR3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOLR3
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.
Cellular Location Secreted.
Tissue Location Spleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the folate receptor (FOLR)family, members of which have a high affinity for folic acid andfor several reduced folic acid derivatives, and mediate delivery of5-methyltetrahydrofolate to the interior of cells. This geneincludes two polymorphic variants; the shorter one has two basedeletion in the CDS, resulting in a truncated polypeptide, comparedto the longer one. Both protein products are constitutivelysecreted in hematopoietic tissues and are potential serum markerfor certain hematopoietic malignancies. The longer protein has a71% and 79% sequence homology with the FOLR1 and FOLR2 proteins,respectively.

References

O'Byrne, M.R., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(8):689-694(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009)Franke, B., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 85(3):216-226(2009)Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :

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$ 277.78
Cat# BP13617a
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Availability: 2 weeks
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