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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   TNN Antibody (Center) Blocking peptide   

TNN Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UQP3
Clone Names 100406292
Peptide ID 100406292
Additional Information
Gene ID 63923
Other Names Tenascin-N, TN-N, TNN
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13618c was selected from the Center region of TNN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNN (HGNC:22942)
Function Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothelial cell layer of the clood vessels (PubMed:19884327).
Research Areas
Citations (0)

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Background

TNN is involved in neurite outgrowth and cell migration in hippocampal explants (By similarity).

References

Gylfe, A.E., et al. Int. J. Cancer (2010) In press :Degen, M., et al. Int. J. Cancer 122(11):2454-2461(2008)Degen, M., et al. Cancer Res. 67(19):9169-9179(2007)Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)Scherberich, A., et al. Oncogene 24(9):1525-1532(2005)

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$ 80.00
Cat# BP13618c
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