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MUC1/EMA Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P15941
Clone Names 101229055
Peptide ID 101229055
Additional Information
Gene ID 4582
Other Names Mucin-1, MUC-1, Breast carcinoma-associated antigen DF3, Cancer antigen 15-3, CA 15-3, Carcinoma-associated mucin, Episialin, H23AG, Krebs von den Lungen-6, KL-6, PEMT, Peanut-reactive urinary mucin, PUM, Polymorphic epithelial mucin, PEM, Tumor-associated epithelial membrane antigen, EMA, Tumor-associated mucin, CD227, Mucin-1 subunit alpha, MUC1-NT, MUC1-alpha, Mucin-1 subunit beta, MUC1-beta, MUC1-CT, MUC1, PUM
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13623b was selected from the C-term region of MUC1/EMA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MUC1
Synonyms PUM
Function The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
Cellular Location Apical cell membrane; Single- pass type I membrane protein. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions Isoform Y: Secreted. Mucin-1 subunit beta: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus
Tissue Location Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 is expressed in tumor cells only.
Research Areas
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This gene is a member of the mucin family and encodes amembrane bound, glycosylated phosphoprotein. The protein isanchored to the apical surface of many epithelia by a transmembranedomain, with the degree of glycosylation varying with cell type. Italso includes a 20 aa variable number tandem repeat (VNTR) domain,with the number of repeats varying from 20 to 120 in differentindividuals. The protein serves a protective function by binding topathogens and also functions in a cell signaling capacity.Overexpression, aberrant intracellular localization, and changes inglycosylation of this protein have been associated with carcinomas.Multiple alternatively spliced transcript variants that encodedifferent isoforms of this gene have been reported, but thefull-length nature of only some has been determined. [provided byRefSeq].


Behrens, M.E., et al. Oncogene 29(42):5667-5677(2010)Lacunza, E., et al. Cancer Genet. Cytogenet. 201(2):102-110(2010)Meyer, T.E., et al. PLoS Genet. 6 (8) (2010) :Beatson, R.E., et al. Immunotherapy 2(3):305-327(2010)Caffery, B., et al. Mol. Vis. 16, 1720-1727 (2010) :

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$ 80.00
Cat# BP13623b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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