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TXNDC3 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N427 |
|---|---|
| Clone Names | 110111051 |
| Gene ID | 51314 |
|---|---|
| Other Names | Thioredoxin domain-containing protein 3, NM23-H8, NME/NM23 family member 8, Spermatid-specific thioredoxin-2, Sptrx-2, NME8, SPTRX2, TXNDC3 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13625c was selected from the Center region of TXNDC3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NME8 (HGNC:16473) |
|---|---|
| Synonyms | SPTRX2, TXNDC3 |
| Function | Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. In vitro, it has neither nucleoside diphosphate kinase (NDPK) activity nor reducing activity on disulfide bonds (PubMed:11737268). Exhibits a 3'-5' exonuclease activity with a preference for single-stranded DNA, suggesting roles in DNA proofreading and repair (PubMed:16313181). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Testis-specific. Expressed only in primary spermatocytes and round spermatids. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein with an N-terminal thioredoxindomain and three C-terminal nucleoside diphosphate kinase (NDK)domains, but the NDK domains are thought to be catalyticallyinactive. The sea urchin ortholog of this gene encodes a componentof sperm outer dynein arms, and the protein is implicated inciliary function. Mutations in this gene are implicated in primaryciliary dyskinesia type 6.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)Desvignes, T., et al. BMC Evol. Biol. 9, 256 (2009) :Shi, D., et al. Arthritis Res. Ther. 10 (3), R54 (2008) :Duriez, B., et al. Proc. Natl. Acad. Sci. U.S.A. 104(9):3336-3341(2007)
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