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TXNDC3 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q8N427
Clone Names 110111051
Peptide ID 110111051
Additional Information
Gene ID 51314
Other Names Thioredoxin domain-containing protein 3, NM23-H8, NME/NM23 family member 8, Spermatid-specific thioredoxin-2, Sptrx-2, NME8, SPTRX2, TXNDC3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13625c was selected from the Center region of TXNDC3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NME8
Synonyms SPTRX2, TXNDC3
Function Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.
Cellular Location Cytoplasm.
Tissue Location Testis-specific. Expressed only in primary spermatocytes and round spermatids.
Research Areas
Citations (0)

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This gene encodes a protein with an N-terminal thioredoxindomain and three C-terminal nucleoside diphosphate kinase (NDK)domains, but the NDK domains are thought to be catalyticallyinactive. The sea urchin ortholog of this gene encodes a componentof sperm outer dynein arms, and the protein is implicated inciliary function. Mutations in this gene are implicated in primaryciliary dyskinesia type 6.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)Desvignes, T., et al. BMC Evol. Biol. 9, 256 (2009) :Shi, D., et al. Arthritis Res. Ther. 10 (3), R54 (2008) :Duriez, B., et al. Proc. Natl. Acad. Sci. U.S.A. 104(9):3336-3341(2007)

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$ 80.00
Cat# BP13625c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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