|Other Names||Thioredoxin domain-containing protein 3, NM23-H8, NME/NM23 family member 8, Spermatid-specific thioredoxin-2, Sptrx-2, NME8, SPTRX2, TXNDC3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13625c was selected from the Center region of TXNDC3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.|
|Tissue Location||Testis-specific. Expressed only in primary spermatocytes and round spermatids.|
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This gene encodes a protein with an N-terminal thioredoxindomain and three C-terminal nucleoside diphosphate kinase (NDK)domains, but the NDK domains are thought to be catalyticallyinactive. The sea urchin ortholog of this gene encodes a componentof sperm outer dynein arms, and the protein is implicated inciliary function. Mutations in this gene are implicated in primaryciliary dyskinesia type 6.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)Desvignes, T., et al. BMC Evol. Biol. 9, 256 (2009) :Shi, D., et al. Arthritis Res. Ther. 10 (3), R54 (2008) :Duriez, B., et al. Proc. Natl. Acad. Sci. U.S.A. 104(9):3336-3341(2007)
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