|Other Names||Tripartite motif-containing protein 34, Interferon-responsive finger protein 1, RING finger protein 21, TRIM34, IFP1, RNF21|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13644a was selected from the N-term region of TRIM34. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as antiviral protein and may contribute to the defense against retroviral infections.|
|Tissue Location||Isoform 1 is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, B-box type 1 and B-box type 2 domain,and a coiled-coil region. Expression of this gene is up-regulatedby interferon. This gene is mapped to chromosome 11p15, where itresides within a TRIM gene cluster. Alternative splicing results inmultiple transcript variants. A read-through transcript from theupstream TRIM6 gene has also been observed, which results in afusion product from these neighboring family members. [provided byRefSeq].
Sawyer, S.L., et al. PLoS Pathog. 3 (12), E197 (2007) :Li, X., et al. Virology 360(2):419-433(2007)Zhang, F., et al. Virology 353(2):396-409(2006)Li, X., et al. J. Virol. 80(13):6198-6206(2006)Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
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