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TRIM45 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H8W5 |
|---|---|
| Clone Names | 100408331 |
| Gene ID | 80263 |
|---|---|
| Other Names | Tripartite motif-containing protein 45, RING finger protein 99, TRIM45, RNF99 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13645b was selected from the C-term region of TRIM45. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TRIM45 |
|---|---|
| Synonyms | RNF99 |
| Function | E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779). Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response (PubMed:36681779). May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Expressed in skeletal muscle, brain, heart and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the tripartite motif family.The encoded protein may function as a transcriptional repressor ofthe mitogen-activated protein kinase pathway. Alternatively splicedtranscript variants have been described.
References
Sardiello, M., et al. BMC Evol. Biol. 8, 225 (2008) :Wang, Y., et al. Biochem. Biophys. Res. Commun. 323(1):9-16(2004)
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