|Other Names||Histone deacetylase 7, HD7, Histone deacetylase 7A, HD7a, HDAC7, HDAC7A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13647b was selected from the C-term region of HDAC7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).|
|Cellular Location||Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation|
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Provided below are standard protocols that you may find useful for product applications.
Histones play a critical role in transcriptionalregulation, cell cycle progression, and developmental events.Histone acetylation/deacetylation alters chromosome structure andaffects transcription factor access to DNA. The protein encoded bythis gene has sequence homology to members of the histonedeacetylase family. This gene is orthologous to mouse HDAC7 genewhose protein promotes repression mediated via the transcriptionalcorepressor SMRT. Alternatively spliced transcript variantsencoding different isoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Margariti, A., et al. Circ. Res. 106(7):1202-1211(2010)Hutt, D.M., et al. Nat. Chem. Biol. 6(1):25-33(2010)Malik, S., et al. Mol. Cell. Biol. 30(2):399-412(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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