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ATG2A Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q2TAZ0
Clone Names 100409002
Additional Information
Gene ID 23130
Other Names Autophagy-related protein 2 homolog A, ATG2A, KIAA0404
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13648c was selected from the Center region of ATG2A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATG2A {ECO:0000303|PubMed:21887408, ECO:0000312|HGNC:HGNC:29028}
Function Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:31271352, PubMed:30952800). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:31271352, PubMed:30952800). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:31271352, PubMed:30952800). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066).
Cellular Location Preautophagosomal structure membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96BY7}. Lipid droplet {ECO:0000250|UniProtKB:Q96BY7}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P53855}. Note=Localizes to endoplasmic reticulum-autophagosome contact sites.
Research Areas
Citations (0)
citation

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Background

The function of this protein remains unknown.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :Guru, S.C., et al. Genome Res. 7(7):725-735(1997)

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$ 277.78
Cat# BP13648c
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Availability: 2 weeks
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