|Other Names||Sjoegren syndrome/scleroderma autoantigen 1, Autoantigen p27, SSSCA1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13654a was selected from the N-term region of SSSCA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.|
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Provided below are standard protocols that you may find useful for product applications.
This antigen is recognized by a subset of anti-centromereantibodies from patients with scleroderma and/or Sjogren'ssyndrome. Subcellular localization has not yet been established.
Shen, A., et al. Neurosurgery 65(1):153-159(2009)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Suzuki, H., et al. Genome Res. 11(10):1758-1765(2001)Muro, Y., et al. Clin. Exp. Immunol. 111(2):372-376(1998)
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