|Other Names||Sulfhydryl oxidase 2, Neuroblastoma-derived sulfhydryl oxidase, Quiescin Q6-like protein 1, QSOX2, QSCN6L1, SOXN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13657c was selected from the Center region of QSOX2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.|
|Cellular Location||Membrane; Single-pass membrane protein Secreted. Cell membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane|
|Tissue Location||Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
QSOX2 is a member of the sulfhydryl oxidase/quiescin-6(Q6) family (QSOX1; MIM 603120) that regulates the sensitization ofneuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced celldeath (Wittke et al., 2003 [PubMed 14633699]).
Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)Olsen, J.V., et al. Cell 127(3):635-648(2006)Humphray, S.J., et al. Nature 429(6990):369-374(2004)Wittke, I., et al. Cancer Res. 63(22):7742-7752(2003)Thorpe, C., et al. Arch. Biochem. Biophys. 405(1):1-12(2002)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.