|Other Names||Sulfhydryl oxidase 2, Neuroblastoma-derived sulfhydryl oxidase, Quiescin Q6-like protein 1, QSOX2, QSCN6L1, SOXN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13657c was selected from the Center region of QSOX2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.|
|Cellular Location||Membrane; Single-pass membrane protein Secreted. Cell membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane|
|Tissue Location||Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles.|
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Provided below are standard protocols that you may find useful for product applications.
QSOX2 is a member of the sulfhydryl oxidase/quiescin-6(Q6) family (QSOX1; MIM 603120) that regulates the sensitization ofneuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced celldeath (Wittke et al., 2003 [PubMed 14633699]).
Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)Olsen, J.V., et al. Cell 127(3):635-648(2006)Humphray, S.J., et al. Nature 429(6990):369-374(2004)Wittke, I., et al. Cancer Res. 63(22):7742-7752(2003)Thorpe, C., et al. Arch. Biochem. Biophys. 405(1):1-12(2002)
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