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QSOX2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6ZRP7 |
|---|---|
| Clone Names | 100416054 |
| Gene ID | 169714 |
|---|---|
| Other Names | Sulfhydryl oxidase 2, Neuroblastoma-derived sulfhydryl oxidase, Quiescin Q6-like protein 1, QSOX2, QSCN6L1, SOXN |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13657c was selected from the Center region of QSOX2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | QSOX2 |
|---|---|
| Synonyms | QSCN6L1, SOXN |
| Function | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. |
| Cellular Location | Membrane; Single- pass membrane protein. Secreted. Cell membrane; Single-pass membrane protein. Nucleus membrane; Single- pass membrane protein. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane |
| Tissue Location | Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles. |
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Provided below are standard protocols that you may find useful for product applications.
Background
QSOX2 is a member of the sulfhydryl oxidase/quiescin-6(Q6) family (QSOX1; MIM 603120) that regulates the sensitization ofneuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced celldeath (Wittke et al., 2003 [PubMed 14633699]).
References
Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)Olsen, J.V., et al. Cell 127(3):635-648(2006)Humphray, S.J., et al. Nature 429(6990):369-374(2004)Wittke, I., et al. Cancer Res. 63(22):7742-7752(2003)Thorpe, C., et al. Arch. Biochem. Biophys. 405(1):1-12(2002)
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