|Other Names||Beta-1, 4-N-acetylgalactosaminyltransferase 3, B4GalNAcT3, Beta4GalNAc-T3, Beta4GalNAcT3, Beta-1, 4-N-acetylgalactosaminyltransferase III, N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2, NGalNAc-T2, B4GALNT3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13658c was selected from the Center region of B4GALNT3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'- diacetyllactosediamine formation on gastric mucosa.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Localizes to apical Golgi|
|Tissue Location||Highly expressed in testis, colon and stomach. Weakly expressed in other tissues.|
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Provided below are standard protocols that you may find useful for product applications.
B4GALNT3 transfers N-acetylgalactosamine (GalNAc) ontoglucosyl residues to form N,N-prime-diacetyllactosediamine(LacdiNAc, or LDN), a unique terminal structure of cell surfaceN-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied byOMIM].
Rose, J. Phd, et al. Mol. Med. (2010) In press :Arking, D.E., et al. PLoS ONE 5 (3), E9879 (2010) :Miller, E., et al. J. Biol. Chem. 283(4):1985-1991(2008)Huang, J., et al. Mol. Cancer Res. 5(6):543-552(2007)Ikehara, Y., et al. Glycobiology 16(9):777-785(2006)
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