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YY2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O15391 |
|---|---|
| Clone Names | 100416122 |
| Gene ID | 404281 |
|---|---|
| Other Names | Transcription factor YY2, Yin and yang 2, YY-2, Zinc finger protein 631, YY2, ZNF631 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13666b was selected from the C-term region of YY2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | YY2 |
|---|---|
| Synonyms | ZNF631 |
| Function | Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in kidney, liver, spleen and testis but not in colon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a transcription factorthat includes several Kruppel-like zinc fingers in its C-terminalregion. It possesses both activation and repression domains, and itcan therefore have both positive and negative effects on thetranscription of target genes. This gene has an intronless codingregion, and it appears to have arisen by retrotransposition of therelated YY1 transcription factor gene, which is located onchromosome 14.
References
Chen, L., et al. Nucleic Acids Res. 38(12):4011-4026(2010)Klar, M., et al. Gene 430 (1-2), 58-63 (2009) :Kim, J.D., et al. Nucleic Acids Res. 35(10):3442-3452(2007)Luo, C., et al. Genomics 87(3):348-355(2006)Klar, M., et al. Mol. Cell. Biol. 25(22):10159-10170(2005)
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