PAQR6 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6TCH4 |
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Clone Names | 100416127 |
Gene ID | 79957 |
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Other Names | Progestin and adipoQ receptor family member 6, Progestin and adipoQ receptor family member VI, PAQR6 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13667b was selected from the C-term region of PAQR6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PAQR6 (HGNC:30132) |
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Function | Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23763432, PubMed:23161870). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Brain specific (PubMed:16044242, PubMed:23763432). Highly expressed in the hypothalamus, also expressed in forebrain, amygdala, corpus callosum and spinal cord (PubMed:23161870) |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein remains unknown.
References
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Smith, J.L., et al. Steroids 73(11):1160-1173(2008)Tang, Y.T., et al. J. Mol. Evol. 61(3):372-380(2005)
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