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PAQR6 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6TCH4
Clone Names 100416127
Additional Information
Gene ID 79957
Other Names Progestin and adipoQ receptor family member 6, Progestin and adipoQ receptor family member VI, PAQR6
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13667b was selected from the C-term region of PAQR6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAQR6 (HGNC:30132)
Function Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23763432, PubMed:23161870).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Brain specific (PubMed:16044242, PubMed:23763432). Highly expressed in the hypothalamus, also expressed in forebrain, amygdala, corpus callosum and spinal cord (PubMed:23161870)
Research Areas
Citations (0)
citation

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Background

The function of this protein remains unknown.

References

Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Smith, J.L., et al. Steroids 73(11):1160-1173(2008)Tang, Y.T., et al. J. Mol. Evol. 61(3):372-380(2005)

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$ 277.78
Cat# BP13667b
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Availability: 2 weeks
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