|Other Names||Mitochondrial import inner membrane translocase subunit Tim8 B, DDP-like protein, Deafness dystonia protein 2, TIMM8B, DDP2, DDPL, TIM8B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13671c was selected from the Center region of TIMM8B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DDP2, DDPL, TIM8B|
|Function||Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).|
|Cellular Location||Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side|
|Tissue Location||Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a well-conserved family ofproteins with similarity to yeast Tim mitochondrial importproteins. This gene is encoded by a nuclear gene and is transportedinto the intermembrane space of the mitochondrion. When formed intocomplexes, these proteins guide membrane-spanning proteins acrossthe mitochondrial intermembrane space before they are added intothe mitochondrial inner membrane. This gene is adjacent tosuccinate dehydrogenase, subunit D (SDHD), in which mutations havebeen found in affected members of families with hereditaryparaganglioma.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Bauer, M.F., et al. FEBS Lett. 464 (1-2), 41-47 (1999) :Jin, H., et al. Genomics 61(3):259-267(1999)
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