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TIMM8B Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y5J9
Clone Names 100416158
Additional Information
Gene ID 26521
Other Names Mitochondrial import inner membrane translocase subunit Tim8 B, DDP-like protein, Deafness dystonia protein 2, TIMM8B, DDP2, DDPL, TIM8B
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13671c was selected from the Center region of TIMM8B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TIMM8B
Synonyms DDP2, DDPL, TIM8B
Function Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
Cellular Location Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
Tissue Location Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of a well-conserved family ofproteins with similarity to yeast Tim mitochondrial importproteins. This gene is encoded by a nuclear gene and is transportedinto the intermembrane space of the mitochondrion. When formed intocomplexes, these proteins guide membrane-spanning proteins acrossthe mitochondrial intermembrane space before they are added intothe mitochondrial inner membrane. This gene is adjacent tosuccinate dehydrogenase, subunit D (SDHD), in which mutations havebeen found in affected members of families with hereditaryparaganglioma.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Bauer, M.F., et al. FEBS Lett. 464 (1-2), 41-47 (1999) :Jin, H., et al. Genomics 61(3):259-267(1999)

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$ 277.78
Cat# BP13671c
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Availability: 2 weeks
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