|Other Names||Receptor-transporting protein 3, Transmembrane protein 7, RTP3, TMEM7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13682a was selected from the N-term region of RTP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43.|
|Cellular Location||Membrane; Single-pass type III membrane protein|
|Tissue Location||Expressed predominantly in adult liver (PubMed:11896456, PubMed:17693185). Expressed in testis (PubMed:16720576, PubMed:17693185). Also expressed in kidney, lung and fetal liver (PubMed:17693185). Low levels in heart, thyroid, adrenal gland, pancreas, ovary, prostate, skin, plasma leukocytes, bone marrow and fetal brain (PubMed:17693185). Not detected in brain, spleen, colon, small intestine, skeletal muscle, stomach, placenta, salivary gland and uterus (PubMed:17693185)|
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Provided below are standard protocols that you may find useful for product applications.
The function of this protein remains unknown.
Zhao, L.J., et al. J. Bone Miner. Res. 25(2):320-329(2010)Zhou, X., et al. Cancer Genet. Cytogenet. 177(1):6-15(2007)Behrens, M., et al. J. Biol. Chem. 281(29):20650-20659(2006)Clark, A.J., et al. Trends Endocrinol. Metab. 16(10):451-457(2005)Saito, H., et al. Cell 119(5):679-691(2004)
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