|Other Names||Hyaluronidase-4, Hyal-4, Chondroitin sulfate endo-beta-N-acetylgalactosaminidase, Chondroitin sulfate hydrolase, CSHY, Hyaluronoglucosaminidase-4, HYAL4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13683c was selected from the Center region of HYAL4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Detected in placenta and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which is similar in structureto hyaluronidases. Hyaluronidases intracellularly degradehyaluronan, one of the major glycosaminoglycans of theextracellular matrix. Hyaluronan is thought to be involved in cellproliferation, migration and differentiation. However, this proteinhas not yet been shown to have hyaluronidase activity. [provided byRefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kaneiwa, T., et al. Glycobiology 20(3):300-309(2010)Fiszer-Szafarz, B., et al. J. Biochem. Biophys. Methods 45(2):103-116(2000)Csoka, A.B., et al. Genomics 60(3):356-361(1999)
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