Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
P4HA3 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q7Z4N8 |
|---|---|
| Clone Names | 100422047 |
| Gene ID | 283208 |
|---|---|
| Other Names | Prolyl 4-hydroxylase subunit alpha-3, 4-PH alpha-3, Procollagen-proline, 2-oxoglutarate-4-dioxygenase subunit alpha-3, P4HA3 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13685c was selected from the Center region of P4HA3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | P4HA3 |
|---|---|
| Function | Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. |
| Cellular Location | Endoplasmic reticulum lumen. |
| Tissue Location | Highly expressed in placenta, liver and fetal skin. Weakly expressed in fetal epiphyseal cartilage, fetal liver, fibroblast, lung and skeletal muscle. Expressed also in fibrous cap of carotid atherosclerotic lesions. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a component of prolyl 4-hydroxylase, akey enzyme in collagen synthesis composed of two identical alphasubunits and two beta subunits. The encoded protein is one ofseveral different types of alpha subunits and provides the majorpart of the catalytic site of the active enzyme. In collagen andrelated proteins, prolyl 4-hydroxylase catalyzes the formation of4-hydroxyproline that is essential to the proper three-dimensionalfolding of newly synthesized procollagen chains. Alternativelyspliced transcript variants have been observed, but theirfull-length nature has not been determined.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Koivunen, P., et al. J. Biol. Chem. 281(39):28712-28720(2006)Kukkola, L., et al. J. Biol. Chem. 278(48):47685-47693(2003)Van Den Diepstraten, C., et al. Circulation 108(5):508-511(2003)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
