|Other Names||Hemoglobin subunit gamma-1, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain, HBG1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13696c was selected from the Center region of HBG1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.|
|Tissue Location||Red blood cells.|
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Provided below are standard protocols that you may find useful for product applications.
The gamma globin genes (HBG1 and HBG2) are normallyexpressed in the fetal liver, spleen and bone marrow. Two gammachains together with two alpha chains constitute fetal hemoglobin(HbF) which is normally replaced by adult hemoglobin (HbA) atbirth. In some beta-thalassemias and related conditions, gammachain production continues into adulthood. The two types of gammachains differ at residue 136 where glycine is found in the G-gammaproduct (HBG2) and alanine is found in the A-gamma product (HBG1).The former is predominant at birth. The order of the genes in thebeta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta-- beta--3'.
Zhou, D., et al. Nat. Genet. 42(9):742-744(2010)Miccio, A., et al. Mol. Cell. Biol. 30(14):3460-3470(2010)Nuinoon, M., et al. Hum. Genet. (2009) In press :da Cunha, A.F., et al. Hemoglobin 33(6):439-447(2009)Hamid, M., et al. Hemoglobin 33(6):428-438(2009)
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