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CRYAB Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P02511
Clone Names 100427027
Peptide ID 100427027
Additional Information
Gene ID 1410
Other Names Alpha-crystallin B chain, Alpha(B)-crystallin, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component, CRYAB, CRYA2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13697c was selected from the Center region of CRYAB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CRYA2
Function May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
Cellular Location Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles
Tissue Location Lens as well as other tissues.
Research Areas
Citations (0)

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Crystallins are separated into two classes:taxon-specific, or enzyme, and ubiquitous. The latter classconstitutes the major proteins of vertebrate eye lens and maintainsthe transparency and refractive index of the lens. Since lenscentral fiber cells lose their nuclei during development, thesecrystallins are made and then retained throughout life, making themextremely stable proteins. Mammalian lens crystallins are dividedinto alpha, beta, and gamma families; beta and gamma crystallinsare also considered as a superfamily. Alpha and beta families arefurther divided into acidic and basic groups. Seven protein regionsexist in crystallins: four homologous motifs, a connecting peptide,and N- and C-terminal extensions. Alpha crystallins are composed oftwo gene products: alpha-A and alpha-B, for acidic and basic,respectively. Alpha crystallins can be induced by heat shock andare members of the small heat shock protein (sHSP also known as theHSP20) family. They act as molecular chaperones although they donot renature proteins and release them in the fashion of a truechaperone; instead they hold them in large soluble aggregates.Post-translational modifications decrease the ability to chaperone.These heterogeneous aggregates consist of 30-40 subunits; thealpha-A and alpha-B subunits have a 3:1 ratio, respectively. Twoadditional functions of alpha crystallins are an autokinaseactivity and participation in the intracellular architecture.Alpha-A and alpha-B gene products are differentially expressed;alpha-A is preferentially restricted to the lens and alpha-B isexpressed widely in many tissues and organs. Elevated expression ofalpha-B crystallin occurs in many neurological diseases; a missensemutation cosegregated in a family with a desmin-related myopathy.


Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010)Jehle, S., et al. Nat. Struct. Mol. Biol. 17(9):1037-1042(2010)Kida, E., et al. J. Neuropathol. Exp. Neurol. 69(7):745-759(2010)Deng, Y., et al. BMB Rep 43(6):432-437(2010)Houck, S.A., et al. PLoS ONE 5 (7), E11795 (2010) :

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$ 80.00
Cat# BP13697c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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