|Other Names||Glycogen phosphorylase, brain form, PYGB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13699a was selected from the N-term region of PYGB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a glycogenphosphorylase found predominantly in the brain. The encoded proteinforms homodimers which can associate into homotetramers, theenzymatically active form of glycogen phosphorylase. The activityof this enzyme is positively regulated by AMP and negativelyregulated by ATP, ADP, and glucose-6-phosphate. This enzymecatalyzes the rate-determining step in glycogen degradation.
Pudil, R., et al. Clin. Chem. Lab. Med. 48(8):1193-1195(2010)Martins-de-Souza, D., et al. J Psychiatr Res (2010) In press :Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
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