|Other Names||Histone H2A type 2-B, HIST2H2AB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13703a was selected from the N-term region of HIST2H2AB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|
|Cellular Location||Nucleus. Chromosome.|
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Provided below are standard protocols that you may find useful for product applications.
Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNAwrapped around a histone octamer composed of pairs of each of thefour core histones (H2A, H2B, H3, and H4). The chromatin fiber isfurther compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatinstructures. This gene is intronless and encodes a member of thehistone H2A family. Transcripts from this gene contain apalindromic termination element.
Bergink, S., et al. Genes Dev. 20(10):1343-1352(2006)Cao, R., et al. Mol. Cell 20(6):845-854(2005)Hagiwara, T., et al. Biochemistry 44(15):5827-5834(2005)Wang, H., et al. Nature 431(7010):873-878(2004)Aihara, H., et al. Genes Dev. 18(8):877-888(2004)
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