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HIST2H2AB Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8IUE6
Clone Names 100427052
Additional Information
Gene ID 317772
Other Names Histone H2A type 2-B, HIST2H2AB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13703a was selected from the N-term region of HIST2H2AB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name H2AC21 (HGNC:20508)
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Cellular Location Nucleus. Chromosome.
Research Areas
Citations (0)
citation

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Background

Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNAwrapped around a histone octamer composed of pairs of each of thefour core histones (H2A, H2B, H3, and H4). The chromatin fiber isfurther compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatinstructures. This gene is intronless and encodes a member of thehistone H2A family. Transcripts from this gene contain apalindromic termination element.

References

Bergink, S., et al. Genes Dev. 20(10):1343-1352(2006)Cao, R., et al. Mol. Cell 20(6):845-854(2005)Hagiwara, T., et al. Biochemistry 44(15):5827-5834(2005)Wang, H., et al. Nature 431(7010):873-878(2004)Aihara, H., et al. Genes Dev. 18(8):877-888(2004)

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$ 277.78
Cat# BP13703a
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Availability: 2 weeks
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