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MCL1 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q07820
Clone Names 100427058
Peptide ID 100427058
Additional Information
Gene ID 4170
Other Names Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, MCL1, BCL2L3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13704c was selected from the Center region of MCL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCL1
Synonyms BCL2L3
Function Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Cellular Location Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria
Research Areas
Citations (0)

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This gene encodes an anti-apoptotic protein, which is amember of the Bcl-2 family. Alternative splicing results inmultiple transcript variants. The longest gene product (isoform 1)enhances cell survival by inhibiting apoptosis while thealternatively spliced shorter gene products (isoform 2 and isoform3) promote apoptosis and are death-inducing.


Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kim, J.H., et al. FEBS Lett. 583(17):2758-2764(2009)Maurer, U., et al. Mol. Cell 21(6):749-760(2006)Domina, A.M., et al. Oncogene 23(31):5301-5315(2004)

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$ 80.00
Cat# BP13704c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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