|Other Names||Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, MCL1, BCL2L3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13704c was selected from the Center region of MCL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.|
|Cellular Location||Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria|
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This gene encodes an anti-apoptotic protein, which is amember of the Bcl-2 family. Alternative splicing results inmultiple transcript variants. The longest gene product (isoform 1)enhances cell survival by inhibiting apoptosis while thealternatively spliced shorter gene products (isoform 2 and isoform3) promote apoptosis and are death-inducing.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kim, J.H., et al. FEBS Lett. 583(17):2758-2764(2009)Maurer, U., et al. Mol. Cell 21(6):749-760(2006)Domina, A.M., et al. Oncogene 23(31):5301-5315(2004)
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