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MCL1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q07820 |
|---|---|
| Clone Names | 100427058 |
| Gene ID | 4170 |
|---|---|
| Other Names | Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, MCL1, BCL2L3 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13704c was selected from the Center region of MCL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MCL1 |
|---|---|
| Synonyms | BCL2L3 |
| Function | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. |
| Cellular Location | Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm Note=Cytoplasmic, associated with mitochondria |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an anti-apoptotic protein, which is amember of the Bcl-2 family. Alternative splicing results inmultiple transcript variants. The longest gene product (isoform 1)enhances cell survival by inhibiting apoptosis while thealternatively spliced shorter gene products (isoform 2 and isoform3) promote apoptosis and are death-inducing.
References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kim, J.H., et al. FEBS Lett. 583(17):2758-2764(2009)Maurer, U., et al. Mol. Cell 21(6):749-760(2006)Domina, A.M., et al. Oncogene 23(31):5301-5315(2004)
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