|Other Names||Serine protease HTRA2, mitochondrial, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, HTRA2, OMI, PRSS25|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13705a was selected from the N-term region of HTRA2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.|
|Cellular Location||Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID|
|Tissue Location||Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid|
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This gene encodes a serine protease. The protein has beenlocalized in the endoplasmic reticulum and interacts with analternatively spliced form of mitogen-activated protein kinase 14.The protein has also been localized to the mitochondria withrelease to the cytosol following apoptotic stimulus. The protein isthought to induce apoptosis by binding the apoptosis inhibitoryprotein baculoviral IAP repeat-containing 4. Nuclear localizationof this protein has also been observed. Alternate splicing of thisgene results in two transcript variants encoding differentisoforms. Additional transcript variants have been described, buttheir full-length sequences have not been determined. [provided byRefSeq].
Zurawa-Janicka, D., et al. Expert Opin. Ther. Targets 14(7):665-679(2010)Kawamoto, Y., et al. Neuropathol. Appl. Neurobiol. 36(4):331-344(2010)Vande Walle, L., et al. Cell Res. 20(4):421-433(2010)Hartkamp, J., et al. Mol. Cell 37(2):159-171(2010)Kruger, R., et al. Neurobiol. Aging (2009) In press :
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